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Interleukin 15, Recombinant, Human (IL-15)
Interleukin 15, Recombinant, Human (IL-15)
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| Interleukin-15 (IL-15) is an immunomodulating cytokine that stimulated the proliferation of T lymphocytes. It shares many biological properties with IL-2. IL-5 is a potent lymphoid cell growth factor that exerts its biological activities primarily on T cells. It is essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, imflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is a 12.9 kD protein containing 114 amino acid residues. | | | Catalog # | I8437 | | Biological Activity | Fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be | | 0.5ng/ml, corresponding to a specific activity of 2x10e6 units/mg. | | Amino Acid Sequence | MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS | | Responding Cells (partial list) | T cells, NK cells, LAK cells | | Recommended Dilutions | Most in vitro applications, IL-15 exerts its biological activity in the concentration range of 0.1-10ng/ml. Optimal dilutions to be determined by researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 12.9kD | | Source | Human, recombinant (E. coli). | | Purity | ~98% by SDS-PAGE and HPLC. Endotoxin: 0.1ng/ug (1EU/ug) | | Form | Supplied as a lyophilized powder from 10mM sodium phosphate, pH 8.5. Reconstitute in sterile ddH2O to 0.1-1mg/ml. Do not vortex. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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