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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 15, Recombinant, Human (IL-15)

Interleukin 15, Recombinant, Human (IL-15)

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Specifications

Interleukin-15 (IL-15) is an immunomodulating cytokine that stimulated the proliferation of T lymphocytes. It shares many biological properties with IL-2. IL-5 is a potent lymphoid cell growth factor that exerts its biological activities primarily on T cells. It is essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, imflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is a 12.9 kD protein containing 114 amino acid residues.
Catalog #I8437
Biological ActivityFully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be
0.5ng/ml, corresponding to a specific activity of 2x10e6 units/mg.
Amino Acid SequenceMNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
Responding Cells (partial list)T cells, NK cells, LAK cells
Recommended DilutionsMost in vitro applications, IL-15 exerts its biological activity in the concentration range of 0.1-10ng/ml. Optimal dilutions to be determined by researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight12.9kD
SourceHuman, recombinant (E. coli).
Purity~98% by SDS-PAGE and HPLC. Endotoxin: 0.1ng/ug (1EU/ug)
FormSupplied as a lyophilized powder from 10mM sodium phosphate, pH 8.5. Reconstitute in sterile ddH2O to 0.1-1mg/ml. Do not vortex.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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