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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » Interleukin 5, Recombinant, Mouse (Interleukin-5, IL-5, B-cell Growth Factor II, BCGF-II, Cytotoxic T-lymphocyte Inducer, Eosinophil Differentiation Factor, T-cell Replacing Factor, TRF, Il5)

Interleukin 5, Recombinant, Mouse (Interleukin-5, IL-5, B-cell Growth Factor II, BCGF-II,
Cytotoxic T-lymphocyte Inducer, Eosinophil Differentiation Factor, T-cell Replacing
Factor, TRF, Il5)

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Specifications

Mouse Interleukin-5 (mIL-5) is a glycoprotein also known as EDF and TRF. It is involved in B-cell growth and eosinophil activation. IL-5 has been shown to be expressed in Th2, mast cells and eosinophils and is regulated by GATA-3, in addition to other transcription factors. IL-5 signals its biological effect through interaction with the IL-5 receptor (IL-5R). Recombinant mIL-5 is produced in E. coli, comprised of two 113aa chains forming a disulfide-linked homodimer with a molecular weight of 26.2kD.
Catalog #I8437-06R
SourceRecombinant corresponding to mouse IL-5 expressed in E. coli.
AA SequenceMEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
Molecular Weight~26.2kD
Endotoxin Level<0.01ng/ug
Biological ActivityMouse IL-5 is fully biologically active as compared to standard. The ED50, as calculated by the dose-dependent induction of TF-1 cell proliferation, is 1.7ng/ml.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~26.2kD
SourceE. coli
Purity~97% (SDS-PAGE, HPLC)
ConcentrationNot determined
FormSupplied as a lyophilized powder from 20mM sodium phosphate buffer, pH 7.5. Reconstitute with sterile dH2O to 0.1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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