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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 16, Recombinant, Mouse (IL-16)

Interleukin 16, Recombinant, Mouse (IL-16)

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Specifications

Recombinant Murine IL-16 is a proinflammatory cytokine inducing immunomodulatory effects of CD41 lymphocytes, monocytes, and eosinophils via CD4. Comparative analysis of murine and human IL-16 show a high degree of amino acid similarity. The highest similarity (82.1%) was found in the C-terminal region. Chemotaxis experiments with IL-16 of murine and human origin, using murine splenocytes or human T lymphocytes as targets, showed cross-species motility. There is a high degree of structural and functional similarity between human and murine IL-16. Murine IL-16 is comprised of 127 amino acids, with a molecular weight of 13.2kD.
Catalog #I8437-07B
Biological Activity Recombinant mouse IL-16 has full biologicial activity compared to a standard. The activity, determined by dose-dependent chemoattraction of lprimary human T cells, is detectable at ~5ng/ml
AA SequenceMHDLNSSTDS AASASAASDI SVESKEATVC TVTLEKTSAG LGFSLEGGKG SLHGDKPLTI NRIFKGDRTG EMVQPGDEIL QLAGTAVQGL TRFEAWNVIK ALPDGPVTIV IRRTSLQCKQ TTASADS
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight13.2kD
SourceE. coli
Purity95% as determined by reducing and non-reducing SDS-PAGE.
FormSupplied as a lyophilized powder. Reconstitute with sterile dH2O to 0.1mg/ml. For long term storage add 0.1% BSA or HSA. Further dilution can be made in other aqueous solutions.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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