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Interleukin 16, Recombinant, Human (LCF, prIL-16, FLJ16806, FLJ42735, FLJ44234, HST19289 )
Interleukin 16, Recombinant, Human (LCF, prIL-16, FLJ16806, FLJ42735, FLJ44234, HST19289 )
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| IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer. Some IL-16 may exist as a monomer. Only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant crossspecies reactivity. Recombinant human IL-16 is a 13.5kD protein consisting of 130 amino acid residues. | | | Catalog # | I8438 | | Biological Activity | Biological activity is determined by IL-6 abiltiy fo chemoattract CD4+ T-lymphocytes using a concentration range of 1-100ng/ml. For most known in vitro applications, IL-16 exerts it biological activity in the concentration range of 0.1-20ng/ml. | | AA Sequence | MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, carrier protein. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 13.5kD | | Source | Recombinant human Interleukin 16 expressed in E. coli. | | Purity | Highly purified ( 98% by SDS-PAGE analysis). | | Endotoxin | 0.1ng/ug | | Form | Supplied as a lyophilized powder in PBS, pH7.6. | | Reconstituted in ddH2O, carrier protein to a concentration of 0.1-1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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