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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 16, Recombinant, Human (LCF, prIL-16, FLJ16806, FLJ42735, FLJ44234, HST19289 )

Interleukin 16, Recombinant, Human (LCF, prIL-16, FLJ16806, FLJ42735, FLJ44234, HST19289 )

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Specifications

IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer. Some IL-16 may exist as a monomer. Only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant crossspecies reactivity. Recombinant human IL-16 is a 13.5kD protein consisting of 130 amino acid residues.
Catalog #I8438
Biological Activity Biological activity is determined by IL-6 abiltiy fo chemoattract CD4+ T-lymphocytes using a concentration range of 1-100ng/ml. For most known in vitro applications, IL-16 exerts it biological activity in the concentration range of 0.1-20ng/ml.
AA Sequence MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, carrier protein. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight13.5kD
SourceRecombinant human Interleukin 16 expressed in E. coli.
PurityHighly purified ( 98% by SDS-PAGE analysis).
Endotoxin0.1ng/ug
FormSupplied as a lyophilized powder in PBS, pH7.6.
Reconstituted in ddH2O, carrier protein to a concentration of 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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