Interleukin 16, Recombinant, Human, His-tag (IL-16, LCF, prIL-16, FLJ16806, FLJ42735,
FLJ44234, HST19289)
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| Human IL-16 was originally described as Lymphocyte Chemoattractant Factor (LCF), is produced primarily by CD4(+) and CD8(+) T cells and acts as a chemoattractant for lymphocytes, monocytes, eosinophils, dendritic cells and Langerhans cells. Additionally, IL-16 has been reported to upregulate IL-2 receptor (CD25), induce progression of cells to the G(1) phase and suppresses HIV & SIV replication. Other cells which have been shown to express IL-16 are; B-cells, eosinophils, macrophages, epithelial cells, fibroblasts, microglial cells and keratinocytes. Human and Murine IL-16 share a high degree of structural and functional similarity. | | | Catalog # | I8438-01D | | Endotoxin | <0.01ng/ug or <0.1EU/ug as per LAL | | Biological Activity | The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10-100ng/ml, corresponding to a Specific Activity greater than 1000IU/mg. | | Amino Acid Sequence | MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 13.5 kD | | Source | Recombinant, human, E. coli | | Purity | 90% as determined by reducing and non-reducing SDS-PAGE. | | Form | Supplied as a lyophilized powder. Reconstitute with sterile dH2O PBS to 0.1-1mg/ml, which can be further diluted into other aqueous solutions. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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