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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » Interleukin 16, Recombinant, Human, His-Tag (IL-16, LCF, prIL-16, FLJ16806, FLJ42735, FLJ44234, HST19289)

Interleukin 16, Recombinant, Human, His-Tag (IL-16, LCF, prIL-16, FLJ16806, FLJ42735,
FLJ44234, HST19289)

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Specifications

Human IL-16 was originally described as Lymphocyte Chemoattractant Factor (LCF), is produced primarily by CD4(+) and CD8(+) T cells and acts as a chemoattractant for lymphocytes, monocytes, eosinophils, dendritic cells and Langerhans cells. Additionally, IL-16 has been reported to upregulate IL-2 receptor (CD25), induce progression of cells to the G(1) phase and suppresses HIV & SIV replication. Other cells which have been shown to express IL-16 are; B-cells, eosinophils, macrophages, epithelial cells, fibroblasts, microglial cells and keratinocytes. Human and Murine IL-16 share a high degree of structural and functional similarity.
Catalog #I8438-01D
Endotoxin <0.01ng/ug or <0.1EU/ug as per LAL
Biological Activity The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10-100ng/ml, corresponding to a Specific Activity greater than 1000IU/mg.
Amino Acid SequenceMPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight13.5 kD
SourceRecombinant, human, E. coli
Purity90% as determined by reducing and non-reducing SDS-PAGE.
FormSupplied as a lyophilized powder. Reconstitute with sterile dH2O PBS to 0.1-1mg/ml, which can be further diluted into other aqueous solutions.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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