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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 17, Recombinant, Human (IL-17, CTLA8, IL-17A, Interleukin-17A precursor, Cytotoxic T-lymphocyte-associated antigen 8)

Interleukin 17, Recombinant, Human (IL-17, CTLA8, IL-17A, Interleukin-17A precursor,
Cytotoxic T-lymphocyte-associated antigen 8)

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Specifications

Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils.Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. Human, mouse and rat IL-17A show activity on mouse cells. Recombinant human IL-17A is a non-glycosylated, disulfide-linked, homodimer containingtwo 137 amino acid chainss , with a total molecular weight of 31 kD.
Catalog #I8439-02A
Endotoxin 0.1EU/ug (LAL)
Biological ActivityThe ED50 as determined by the dose-dependent induction of IL-6 by mouse NIH 3T3 fibroblasts is 1.4-2.1 ng/ml
AA SequenceMIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. For long term storage a carrier protein (0.1% BSA or HSA) is recommended. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight30.3kD
SourceE. coli
Purity98% (HPLC, reducing and non-reducing SDS-PAGE)
FormSupplied as a lyophilized powder with no additives. Reconstitute with sterile ddH2O to a concentration of 0.1mg/ml. For long term storage a carrier protein (0.1% BSA or HSA) is recommended.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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