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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 17A/F Heterodimer, Recombinant, Mouse (IL-17, CTLA8, IL-17A, Interleukin-17A precursor, Cytotoxic T-lymphocyte-associated antigen 8)

Interleukin 17A/F Heterodimer, Recombinant, Mouse (IL-17, CTLA8, IL-17A, Interleukin-17A
precursor, Cytotoxic T-lymphocyte-associated antigen 8)

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Specifications

Catalog #I8439-02M
SourceTwo DNA sequences encoding the mature mouse IL-17A (Thr 22-Ala 158; Accession #Q62386) and mature mouse IL-17F (Arg 21-Ala 153; Accession # AAM77568) were expressed separately in E. coli.
Molecular MassThe recombinant mouse IL1-7A/IL-17F is a refolded disulfide-linked heterodimer of IL-17A and
IL-17F. The non-methionyl form of rhIL-17A monomer has a predicted molecular mass of 14.9kD whereas the methionyl form of rhIL1-7F monomer has a predicted molecular mass of 15.5kD.
Activity Measured by its ability to stimulate induce IL-6 production by NIH/3T3 cells (Yao, Z. et al., 1995, Immunity 3:811). The ED 50 for this effect is typically 0.075-0.375ug/ml.
Endotoxin 1.0 EU/1ug (LAL)
Storage and Stability12 months from date of receipt, 20 to 70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, 20 to 70°C under sterile conditions after reconstitution.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
SourceE. coli
Purity95% by SDS­PAGE under reducing conditions and visualized by silver stain.
FormSupplied as a lyophilized powder in 0.2um sterile-filtered solution in 30% acetonitrile, 0.1% TFA, 50ug of bBSA per 1ug of cytokine. Reconstitute with sterile 4mM HCI containing at least 0.1% HSA or BSA be added to the vial to prepare a stock solution of 100ug/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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