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Interleukin 17A/F Heterodimer, Recombinant, Mouse (IL-17, CTLA8, IL-17A, Interleukin-17A precursor, Cytotoxic T-lymphocyte-associated antigen 8)
Interleukin 17A/F Heterodimer, Recombinant, Mouse (IL-17, CTLA8, IL-17A, Interleukin-17A
precursor, Cytotoxic T-lymphocyte-associated antigen 8)
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| Catalog # | I8439-02M | | Source | Two DNA sequences encoding the mature mouse IL-17A (Thr 22-Ala 158; Accession #Q62386) and mature mouse IL-17F (Arg 21-Ala 153; Accession # AAM77568) were expressed separately in E. coli. | | Molecular Mass | The recombinant mouse IL1-7A/IL-17F is a refolded disulfide-linked heterodimer of IL-17A and | | IL-17F. The non-methionyl form of rhIL-17A monomer has a predicted molecular mass of 14.9kD whereas the methionyl form of rhIL1-7F monomer has a predicted molecular mass of 15.5kD. | | Activity | Measured by its ability to stimulate induce IL-6 production by NIH/3T3 cells (Yao, Z. et al., 1995, Immunity 3:811). The ED 50 for this effect is typically 0.075-0.375ug/ml. | | Endotoxin | 1.0 EU/1ug (LAL) | | Storage and Stability | 12 months from date of receipt, 20 to 70°C as supplied. | | 1 month, 2 to 8°C under sterile conditions after reconstitution. | | 3 months, 20 to 70°C under sterile conditions after reconstitution. | | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. | | Source | E. coli | | Purity | 95% by SDSPAGE under reducing conditions and visualized by silver stain. | | Form | Supplied as a lyophilized powder in 0.2um sterile-filtered solution in 30% acetonitrile, 0.1% TFA, 50ug of bBSA per 1ug of cytokine. Reconstitute with sterile 4mM HCI containing at least 0.1% HSA or BSA be added to the vial to prepare a stock solution of 100ug/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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