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Interleukin 17, Recombinant, Human (IL-17, CTLA8, IL-17A, Interleukin-17A precursor, Cytotoxic T-lymphocyte-associated antigen 8)
Interleukin 17, Recombinant, Human (IL-17, CTLA8, IL-17A, Interleukin-17A precursor,
Cytotoxic T-lymphocyte-associated antigen 8)
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| The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 132 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.0kD disulfide-linked homodimer of two 136 amino acid polypeptide chains. | | | Catalog # | I8439-04B | | Source | Escherichia coli. | | Biological Activity | The ED50 as determined by the dose-dependent induction of IL-17 in primary human foreskin fibroblasts was found to be approximately 2ng/ml. | | Endotoxin | 1EU/ug (LAL) | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. Reconstitute with sterile ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 1 month at 4 °C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | ~15kD | | Source | E. coli | | Purity | 95% as determined by SDS-PAGE and HPLC. | | Form | Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 50ug of HSA per 1ug of cytokine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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