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Anti -Interleukin 17 (IL-17, CTLA8, IL-17A, Interleukin-17A Precursor, Cytotoxic T-lymphocyte-associated Antigen 8) (Biotin)
Anti -Interleukin 17 (IL-17, CTLA8, IL-17A, Interleukin-17A Precursor, Cytotoxic
T-lymphocyte-associated Antigen 8) (Biotin)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Purified |
E |
|
| Interleukin 17 is a 32kD disulfide-linked homodimer consisting of two 136 amino acid chains, which belongs to the IL-17 family (classified as IL-17A to IL-17F), and signals through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction. | | | Catalog # | I8439-04L1 | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 10B2379 | | Host | Rat | | Source | Mouse | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. Labeled with Biotin. | | Purity | Purified | | Immunogen | Mouse Interleukin 17. | | Specificity | Recognizes mouse Interleukin 17. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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