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You are here:Home » Antibodies » Abs to Interleukin » Anti -Interleukin-17 Receptor A (IL17RA, IL-17RA, CDw217, CD217, MGC10262, AW538159) (APC)

Anti -Interleukin-17 Receptor A (IL17RA, IL-17RA, CDw217, CD217, MGC10262, AW538159) (APC)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified FC
Interleukin-17 is a pleotropic cytokine expressed by T cells. IL-17 binds to the IL-17 receptor (IL-17 R), which shares no homology with any other known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The aa sequence of mouse IL-17 R is 69% identical to human IL-17 R. The signaling events mediated by IL-17 include activation of NF-KB and JNK, and require TNF receptor-associated factor 6 (TRAF6) in the signaling pathway.
Catalog #I8439-35H
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. Freezing Allophycocyanin (APC) conjugates will result in a substantial loss of activity. Allophycocyanin (APC) conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2A
Clone No12K116
HostRat
SourceMouse
Concentration~0.025mg/ml
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to aa32-322 from the extracellular domain of mouse IL-17 R expressed in NSO cell line.
SpecificityRecognizes mouse IL-17 R.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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