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You are here:Home » Antibodies » Antibodies-Interleukin » Anti -IL18 (Interleukin-18, Iboctadekin, Interferon gamma-inducing Factor, IFN-gamma-inducing Factor, Interleukin-1 gamma, IL-1 gamma, IGIF, IL1F4)

Anti -IL18 (Interleukin-18, Iboctadekin, Interferon gamma-inducing Factor,
IFN-gamma-inducing Factor, Interleukin-1 gamma, IL-1 gamma, IGIF, IL1F4)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
IL-18, initially described as IFN-g inducing factor (IGIF), is a pro-inflammatory cytokine. It is an 18kD cytokine which identified as a costimulatory factor for production of interferon-y (IFN-y) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24kD molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. The cytokine IL-18 possesses pleiotropic biological properties such as activation of NF-kb, Fas ligand expression, induction of both CC and CXC chemokines, enhancement of the production of IFN-g and GM-CSF, and induction of CD4+ cytolytic T cell response. Its role in neurodegeneartion disease has also been reported.
Catalog #I8439-97G
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-4ug/ml
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 30% glycerol, 0.5% BSA, 0.01% thimerosal.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 41aa of human IL-18.
SpecificityRecognizes human IL18.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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