Anti -IL18 (Interleukin-18, Iboctadekin, Interferon gamma-inducing Factor,
IFN-gamma-inducing Factor, Interleukin-1 gamma, IL-1 gamma, IGIF, IL1F4)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| IL-18, initially described as IFN-g inducing factor (IGIF), is a pro-inflammatory cytokine. It is an 18kD cytokine which identified as a costimulatory factor for production of interferon-y (IFN-y) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24kD molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. The cytokine IL-18 possesses pleiotropic biological properties such as activation of NF-kb, Fas ligand expression, induction of both CC and CXC chemokines, enhancement of the production of IFN-g and GM-CSF, and induction of CD4+ cytolytic T cell response. Its role in neurodegeneartion disease has also been reported. | | | Catalog # | I8439-97G | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-4ug/ml | | Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.2, 30% glycerol, 0.5% BSA, 0.01% thimerosal. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to 41aa of human IL-18. | | Specificity | Recognizes human IL18. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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