You are here:Home
»
Antibodies
»
Abs to Interleukin
»
Anti -IL18BP (Interleukin-18-binding Protein, IL-18BP, Tadekinig-alfa)
Anti -IL18BP (Interleukin-18-binding Protein, IL-18BP, Tadekinig-alfa)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| IL-18BP, a 40kD glycoprotein, is a member of Ig super family. It consists of a single Ig-like domain and acts as a circulating anti-inflammatory protein. It is a secretory protein which binds to IL-18 with high affinity and prevents its interaction with IL-18R, resulting in inhibition of IL-18 induced IFN-gamma, IL-8 and NF-kB production. Its expression is up-regulated by IFN-gamma, thus providing a negative feed-back mechanism in shutting off IL-18 mediated immune responses. It is constitutively expressed in mononuclear cells and its role has been implicated in treatment of contact hypersensitivity. Northern Blot analysis detected a strong expression in spleen and its pathological implications have been observed in Crohn's disease. | | | Catalog # | I8440-02C | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa44-55 [STKDPCPSQPPVC] of the 40kD human IL-18BP. | | Specificity | Recognizes human IL-18BP. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
