Interleukin 21, Recombinant, Mouse (IL-21, Interleukin-21, Il21)
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| Mouse Interleukin-21 (m-IL-21), expressed by activated CD4(+) T cells, is the newest member of the common gamma-chain family of cytokines, which also includes IL-2, IL-4, IL-7, IL-9, and IL-13. Its private receptor, IL-21R, is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. IL-21R has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathways upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, the differentiation, and the effector functions of B, T, natural killer, and dendritic cells. Recombinant mouse IL-21, produced in E. coli, is a single, non-glycosylated polypeptide chain containing 130aa and having a total molecular mass of 15,095Ds. | | | Catalog # | I8442-15M | | Source | Recombinant corresponding to mouse IL-21 expressed in E. coli. | | AA Sequence | MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS | | Molecular Weight | ~15.095kD | | Endotoxin Level | <0.01ng/ug | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | ~15.095kD | | Source | E. coli | | Purity | ~95% (SDS-PAGE, HPLC) | | Concentration | Not determined | | Form | Supplied as a lyophilized powder from 20mM sodium bicarbonate, pH 8.5. Reconstitute with sterile dH2O to 0.1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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