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You are here:Home » Antibodies » Abs to Receptors » Anti -Interleukin 21 Receptor (IL-21R)

Anti -Interleukin 21 Receptor (IL-21R)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E IH
A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21 (1). The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling (3,4). Both IL-21R and the gammac are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Catalog #I8442-22
Applications
Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionsELISA (peptide): 1:100,000
Immunohistochemistry: 1:300
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 1mg/ml BSA, 0.1% sodium azide.
PurityPurified by Immunoffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa 35-46, CVLETRSPNPSIL
SLTWQDEYEELQDQETF of mouse IL-21 receptor.
SpecificityRecognizes N-terminus of mouse IL-21 receptor.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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