Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E IH

A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21 (1). The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling (3,4). Both IL-21R and the gammac are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Catalog #	I8442-22
Applications
	Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended Dilutions	ELISA (peptide): 1:100,000
	Immunohistochemistry: 1:300
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Mouse
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, 1mg/ml BSA, 0.1% sodium azide.
Purity	Purified by Immunoffinity chromatography.
Immunogen	Synthetic peptide corresponding to aa 35-46, CVLETRSPNPSIL
SLTWQDEYEELQDQETF of mouse IL-21 receptor.
Specificity	Recognizes N-terminus of mouse IL-21 receptor.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.