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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » Interleukin 31, Recombinant, Mouse (IL-31)

Interleukin 31, Recombinant, Mouse (IL-31)

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Specifications

IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant murine IL-31 is a 15.8kD protein containing 140 amino acid residues.
Catalog #I8442-40
SourceE. coli
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile ddH2O, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Country of OriginUSA
SourceE. coli
Purity98% by SDS-PAGE and HPLC analyses.
ConcentrationAs reported
FormSupplied as a lyophilized powder from 20mM sodium phosphate, pH 7.5.
ReconstitutionReconstitute sterile ddH2O to a concentration of 0.1-1mg/ml, which can then be further diluted to other aqueous solutions.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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