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Specifications

Clone Host Grade Applications Polyclonal Rabbit Serum E

Interleukin 31 is a cytokine derived from activated Th2-type T cells. It is a secreted protein known to interact with a heterodimeric receptor of IL-31RA and OSMR constitutively expressed on epithelial cells and keratinocytes and thus activate STAT3 and possibly STAT1 and STAT5. Though exact function is not known, reports suggest that it may take part in the promotion of allergic skin disorders and in regulating other allergic diseases such as asthma. It is also known to be a potent inducer of proinflammatory mediators in human colonic SEMFs. IL-31 is upregulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells, and also in lesional biopsies of patients with allergic contact dermatitis (ACD). It shows faint expression in bone marrow, colon, skeletal muscle, kidney, testis, thymus, small intestine and trachea.
Catalog #	I8442-40K
Applications	Suitable for use in ELISA. Other applications not tested.
Recommended Dilution	ELISA: 1:100-1:1000
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	Not determined.
Form	Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Purity	Serum
Immunogen	Synthetic peptide corresponding to aa24-41 (SHTLPVRLLRPSDDVQKI) of human IL-31.
Specificity	Recognizes human IL-31. Species Crossreactivity
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.