Anti -Internexin, alpha (66kD Neurofilament Protein, Alpha Inx, INA, Internexin Neuronal
intermediate Filament Protein alpha, MGC12702, NEF 5, NEF5, Neurofilament 5 (66kD),
Neurofilament 66, Neurofilament 66 Tax Binding Protein, NF 66, NF66, TXBP 1, TXBP1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
B IH IC IF |
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| Neurofilaments are the intermediate filaments found in neuronal cells. They are composed of a combination of subunit proteins which typically includes the neurofilment triplet proteins, NF-L, NF-M, and NF-H. Neurofilaments may also include peripherin, alpha-internexin (NF66), nestin, and vimentin. Neurofilament proteins are useful biomarkers as their expression can vary during neuronal development and differentiation, between between neuronal cell subtypes, and be altered during pathological states. Alpha-internexin/NF66, related to the neurofilament triplet proteins, is expressed during early neuronal development. The temporal and spatial expression pattern of alpha-internexin varies between different subtypes of differentiating and mature neurons. An upregulation of alpha-internexin has been observed during neuronal regeneration. Abnormal neuronal aggregates of alpha-internexin along with N-L, NF-M, and NF-H have been identified as the pathological hallmarks of the neuronal intermediate filament inclusion disease (NIFID), an early onset neurodegenerative disease associated with dementia. Antibodies to alpha-internexin are useful probes for studying and classifying neuronal subtypes, and for identifying neuronal progenitor cells and other cells committed to the neuronal lineage. | | | Catalog # | I8442-74Q | | Applications | Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Immunofluorescence: 1:100-1:1000 | | Western Blot: 1:500-1:2500 | | Immunohistochemistry (frozen, formalin-fixed, paraffin-embeded tissue sections, formalin-fixed tissue cultured cells): 1:2000-1:5000 | | Immunocytochemistry: 1:100-1:1000 | | Optimal dilutions to be determined by the researcher. | | Positive Control | PC12 cells, brain, spinal cord, or nerve tissue | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E243 | | Host | Mouse | | Source | Rat | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.01% thimerosal, 1mg/ml BSA, 50% glycerol. | | Purity | Supernatant | | Immunogen | Recombinant corresponding to rat alpha internexin. | | Specificity | Recognizes rat Internexin, alpha. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Internexin, alpha (66kD Neurofilament Protein, Alpha Inx, INA, Internexin Neuronal intermediate Filament Protein alpha, MGC12702, NEF 5, NEF5, Neurofilament 5 (66kD), Neurofilament 66, Neurofilament 66 Tax Binding Protein, NF 66, NF66, TXBP 1, TXBP1) |
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