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Specifications

Clone Host Grade Applications Monoclonal Mouse Supernatant E B IP IH IC

alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage.
Catalog #	I8442-75
Applications	Suitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation and ELISA . Other applications have not been tested.
Recommended Dilutions
	Immunocytochemistry: PC12 and Ntera-2 cells
	Immunohistochemistry: Paraffin-embedded, formalin and methonal fixed tisues
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	2Q79
Host	Mouse
Source	Rat
Concentration	Not Determined
Form	Supplied as a liquid. Contains no preservative.
Purity	Supernatant
Immunogen	Full length recombinant rat alpha internexin
Specificity	Recognizes the C-terminal “Tail” extension of rat alpha internexin. Species Crossreactivity: human, mouse, feline, rabbit, bovine and porcine
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.