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Specifications

Clone Host Grade Applications Polyclonal Rabbit Serum E B IH IC

alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage.
Catalog #	I8442-76
Application(s)	Immunohistochemistry on formalin or paraformaldehyde fixed tissues. Immunocytochemistry on NTera2 and PC12 cells.
	Western blot
	ELISA
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Rat
Concentration	Not determined
Form	Supplied as a lyophilized powder, containing no preservatives.(Reconsititute with 500ml of sterile distilled water)
Purity	Serum
Immunogen	Full length recombinant rat a-internexin fused to E. coli Trp E
Specificity	Recognizes human, rat, bovine, porcine, mouse and feline internexin, C-terminal globular tail region.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.