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Interleukin 22R, CT, Blocking Peptide (IL-22R CT, CRF2–9, IL-TIF R1, IL-10 Related T Cell-derived Inducible Factor)
Interleukin 22R, CT, Blocking Peptide (IL-22R CT, CRF2–9, IL-TIF R1, IL-10 Related T
Cell-derived Inducible Factor)
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| A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified (1–3). The receptor for IL-22 (IL-22R, also termed CRF2–9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family (3,4). IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently (5–7). IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response. | | | Catalog # | I8443-10P | | Synthetic peptide (DSLFRGLALTVQWES) corresponding to amino acids 560 to 574 of human IL-22R precursor (1). | | Source | Synthetic peptide | | Purity | Purified 60-70% | | Concentration | ~0.2mg/ml | | Form | Supplied as a lyophilized powder. | | Specificity | Human Interleukin-22R. An approximately 62kD band can be detected. | | | Important Note | This product is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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