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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 22R, NT, Blocking Peptide (IL-22R NT, CRF29, IL-TIF R1, IL-10 Related T Cell-derived Inducible Factor)

Interleukin 22R, NT, Blocking Peptide (IL-22R NT, CRF29, IL-TIF R1, IL-10 Related T
Cell-derived Inducible Factor)

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Specifications

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified (13). The receptor for IL-22 (IL-22R, also termed CRF29 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family (3,4). IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently (57). IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
Catalog #I8443-12P
Synthetic peptide (QSSNFENILTWDSGPE) corresponding to amino acids 31 to 46 of human IL-22R precursor (1).
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceSynthetic peptide
PurityPurified 60-70%
Concentration~0.2mg/ml
FormSupplied as a lyophilized powder.
SpecificityHuman Interleukin-22R. An approximately 62kD band can be detected.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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