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Interleukin 23, Recombinant, Human (IL-23)
Interleukin 23, Recombinant, Human (IL-23)
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| IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines (1). It exists as a heterodimer composed of the IL-12 p40 subunit and a novel p19 subunit (2). IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. | | | Catalog # | I8443-40D | | Produced in HEK 293 cells. Mature human IL-23 (interleukin-23) p40 peptide (aa23-328) is fused at the C-terminus to a 18aa linker peptide, GSTSGSGKPGSGEGSTKG and to the mature p19 peptide (aa20-189) and fused at the N-terminus to a FLAG®-tag. | | Biological Activity | Induction of IL-17 secretion by mouse splenocytes. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Purity | 90% (SDS-PAGE) | | Concentration | ~0.5mg/ml | | Endotoxin | 0.1EU/ug protein (LAL). | | Form | Supplied as a sterile-filtered liquid in PBS. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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