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Anti -IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)
Anti -IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| Recently, IL-23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines has been discovered. IL-23 is composed of the IL-12p40 soluble receptor subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. IL-23 mediates it cellular function by binding to IL-23 receptor (IL-23R), which pairs with IL-12Rb1 to confer IL-23 responsiveness. However, human IL-12 does not bind to human IL-23R. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12. | | | Catalog # | I8443-49G | | Applications | Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 0.1-1ug/ml | | Immunohistochemistry (formalin fixed paraffin embedded): 5-10ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Jurkat, NIH3T3 | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa439-455 (EIFIPEHKPTDYKKENT) of human IL-23 receptor, Genbank no NP_653302. | | Specificity | Recognizes human IL-23R. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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