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You are here:Home » Antibodies » Abs to Interleukin » Anti -IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)

Anti -IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Recently, IL-23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines has been discovered. IL-23 is composed of the IL-12p40 soluble receptor subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. IL-23 mediates it cellular function by binding to IL-23 receptor (IL-23R), which pairs with IL-12Rb1 to confer IL-23 responsiveness. However, human IL-12 does not bind to human IL-23R. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12.
Catalog #I8443-49G
ApplicationsSuitable for use in Western Blot, Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-1ug/ml
Immunohistochemistry (formalin fixed paraffin embedded): 5-10ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat, NIH3T3
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa439-455 (EIFIPEHKPTDYKKENT) of human IL-23 receptor, Genbank no NP_653302.
SpecificityRecognizes human IL-23R. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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