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You are here:Home » Antibodies » Antibodies-Interleukin » Anti -IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)

Anti -IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH FC
Recently, IL-23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines has been discovered. IL-23 is composed of the IL-12p40 soluble receptor subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. IL-23 mediates it cellular function by binding to IL-23 receptor (IL-23R), which pairs with IL-12Rb1 to confer IL-23 responsiveness. However, human IL-12 does not bind to human IL-23R. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12.
Catalog #I8443-49G
ApplicationsSuitable for use in Western Blot, Flow Cytometry, and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionWestern Blot: 0.1-1ug/ml
Immunohistochemistry (Paraffin): 5-10ug/ml
Flow Cytometry: 1:10-1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat, NIH3T3
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa439-455 (EIFIPEHKPTDYKKENT) of human IL-23 receptor (NP_653302).
SpecificityRecognizes human IL-23R. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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