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Interleukin 17E, Recombinant, Rat, (IL-17E, IL25, IL-25, Precursor, interleukin 25, Interleukin-25)
Interleukin 17E, Recombinant, Rat, (IL-17E, IL25, IL-25, Precursor, interleukin 25,
Interleukin-25)
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| Interleukin-17E (IL-17E), also commonly called IL-25, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17F stimulates secretion of IL-8 and induces activation of NF-kB by binding to the receptor IL- 17RB. Recombinant rat IL-17E is a non-glycosylated, disulfide-linked homodimer, containing two 145aa proteins and having a total molecular mass of 35.5kD. | | | Catalog # | I8443-61 | | Biological Activity | The activity is measured by the dose-dependent induction of human PBMCs and is typically <100ng/ml. | | Amino Acid Sequence | CSHLPRCCPS KQQEFPEEWL KWNPAPVSPP EPLRHTHHPE SCRASKDGPL NSRAISPWSY ELDRDLNRVP QDLYHARCLC PHCVSLQTGS HMDPMGNSVP LYHNQTVFYR RPCHGEQGAH GRYCLERRLY RVSLACVCVR PRMMA | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 20mM HCl, 0.1% BSA or HSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 35.5kD | | Source | Recominant rat, expressed in E. coli | | Purity | ~95% Analysis by RP-HPLC; Reducing and non-reducing SDS-PAGE. Endotoxin: 0.1ng/ml | | Form | Supplied as a lyophilized powder. Reconstitute with sterile 20mM HCl to 0.1mg/ml. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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