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Anti -IL-27 (Interleukin-27 Subunit alpha, IL-27 Subunit alpha, IL-27-A, IL27-A, p28, IL27A)
Anti -IL-27 (Interleukin-27 Subunit alpha, IL-27 Subunit alpha, IL-27-A, IL27-A, p28,
IL27A)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E |
|
| IL-27 is a 243aa, novel heterodimeric cytokine belonging to the IL-6/IL-12 family and produced by activated antigen-presenting cells. It is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) and p28. Recent reports suggest that IL-27 is a potent inhibitor of HIV-1 replication in PBMCs, CD4 (+) T cells and macrophages. It has antiangiogenic activity, which plays an important role in its antitumor and antimetastatic activities. It is also responsible for early regulation of Th1 adaptive immune response. It strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4 (+) T cells and drives rapid clonal expansion of naive but not memory CD4 (+) T cells through the cytokine receptor WSX-1/TCCR. | | | Catalog # | I8443-75K | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:100-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.025% sodium azide, 50% glycerol. | | Purity | Serum | | Immunogen | Synthetic peptide corresponding to aa141-155 (RLDLRDLQRHLRFQV) of human IL-27. | | Specificity | Recognizes human Interleukin 27. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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