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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -Involucrin (IVL)

Anti -Involucrin (IVL)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Involucrin is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. The gene consists of 585aa, 390 of which form a central decapeptide repeat, rich in glutamine and glutamic acid. The involucrin gene,encoding a protein of the terminally differentiated keratinocyte, is polymorphic in the human. Involucrin has previously been mapped to chromosome 1q21. The epidermal protein involucrin has been remodeled in the higher primates. And the existence of two populations of East Asian involucrin alleles gives support for the existence of a Eurasian stem lineage from which Caucasians and a part of the Asian population originated.
Catalog #I8447-27H
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in 10mM PBS, pH 7.4, BSA, sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa420-578 of human Involucrin.
SpecificityRecognizes human Involucrin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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