IPP-1, aa1-171, Recombinant, Human, His-tag (Inhibitor of Protein Phosphatase)
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| IPP-1, 1-171aa, Human, His-tagged, Recombinant, E. coli | | | Catalog # | I8465-02B | | Full name | Protein phosphatase inhibitor-1 | | NCBI Accession | NP_006732 | | Synonyms | IPP-1, I-1, PPI-1 | | Protein phosphatase inhibitor-1 (IPP-1) plays an important role in the regulation of glycogen metabolism through inhibition of type-1 protein serine/threonine phosphatase(PP1) activity, and it has been implicated in the regulation of cell growth. IPP-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. In the presence of calcium, PPI-1 is inactivated by calcineurin (or PP2B). | | Recombinant human IPP-1, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. | | Molecular Weight | 20kD (179 aa) | | Sequence | MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI | | DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE | | PEGAAESTGT QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE | | PSTKEPSTHI PPLDSKGANS VLEHHHHHH | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 20kD | | Source | Recombinant, E. coli | | Purity | 90% by SDS PAGE | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 50mM Tris, pH 8.0, 0.1mM PMSF, 1mM EDTA, 1mM DTT, 10% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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