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You are here:Home » Antibodies » Abs to Ion Channel » Anti -IP3R1 (ITPR1, inositol 1,4,5-triphosphate receptor, type 1, Inositol 1,4,5-trisphosphate receptor type 1, Insp3r1, InsP3R1, INSP3R1, IP3R, IP3R1, IP3 receptor isoform 1, SCA15, SCA16, Type 1 inositol 1,4,5-trisphosphate receptor, Type 1 InsP3 receptor)

Anti -IP3R1 (ITPR1, inositol 1,4,5-triphosphate receptor, type 1, Inositol
1,4,5-trisphosphate receptor type 1, Insp3r1, InsP3R1, INSP3R1, IP3R, IP3R1, IP3 receptor
isoform 1, SCA15, SCA16, Type 1 inositol 1,4,5-trisphosphate receptor, Type 1 InsP3
receptor)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to the IP3 receptor (IP3R), IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240kD glycoprotein subunits, that is structurally reminiscent of members of the voltage-gated ion channel superfamily. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Cytosolic calcium levels appear to be regulated by a feedback loop that starts with calcium activation of protein kinase C (PKC) and calcineurin, a protein phosphatase. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. Type-I IP3R has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II protein is found predominantly in the brain. Isoform III expression has been shown to occur in pancreatic islets, kidney and the gastrointestinal tract.
Catalog #I8470-04A
Cellular Localization Endoplasmic reticulum-Integral membrane protein.
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2.
PuritySerum
ImmunogenSynthetic peptide: KKKDDEVDRDAPSRKKAKE, corresponding to amino acids 1829-1848 of Human IP3R1. This sequence is 100% conserved in human, mouse, and rat IP3R-I protein.
SpecificitySpecies Crossreactivity: Crossreacts with Rat and canine. Expected to crossreact with Human (100% identity with immunogen) and Mouse (100% identity with immunogen) due to sequence homology. Not yet tested in other species.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesIP3, IP3R


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