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You are here:Home » Antibodies » Abs to Insulin » Anti -Insulysin (IDE, insulin-degrading enzyme, FLJ35968, Insulinase, Insulin-degrading Enzyme, Insulin Protease)

Anti -Insulysin (IDE, insulin-degrading enzyme, FLJ35968, Insulinase, Insulin-degrading
Enzyme, Insulin Protease)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Insulysin, a wide expressed protein, is responsible for the degradation of insulin in cells. Primarily located in the cytosol, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B-chain, glucagon, denatured hemoglobin, alpha-amyloid protein, TGF-alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer's disease research.
Catalog #I8601-02A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 1:32,000
Western Blot: 0.1-0.3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlLysates of cell line K562
Control PeptideI8601-02A-P
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 monthsat -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide, C-QQYNFDRDNTE, from the internal region of human Insulysin.
SpecificityRecognizes human Insulysin at ~120kD. Species sequence homology: canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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