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You are here:Home » Antibodies » Abs to Insulin » Anti -IDE (Insulin-degrading Enzyme, Abeta-degrading Protease, Insulin Protease, Insulinase, Insulysin)

Anti -IDE (Insulin-degrading Enzyme, Abeta-degrading Protease, Insulin Protease,
Insulinase, Insulysin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Insulin Degrading Enzyme (IDE) encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of IDE for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in IDE's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
Catalog #I8601-02H
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:5000-1:20,000
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-glycine, pH 7, 0.01% thimerosal, 10% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa349-605 from human insulin-degrading enzyme.
SpecificityRecognizes human IDE. Species sequence homology: mouse (94%), rat (95%), bovine (98%) and zebrafish (90%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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