You are here:Home
»
Antibodies
»
Abs to Protein Kinase Substrates
»
Anti -IRS1 (Insulin Receptor Substrate 1, IRS-1)
Anti -IRS1 (Insulin Receptor Substrate 1, IRS-1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E |
|
| IRS-1 regulates most insulin responses, including peripheral and central glucose homeostasis, protein synthesis, and cell proliferation and growth. The protein contains an N-terminal pleckstrin homology (PH) domain and phosphotyrosine-binding (PTB) domain which are necessary for targeting IRS-1 to the activated insulin receptor at plasma membrane, where it becomes phosphorylated in response to insulin stimulation of cells. Once phosphorlated by the insulin receptor, the protein binds specifically to various cellular proteins containing Src homology-2 (Sh2) domain, including phosphatidylinositol 3-kinase (PI-3K), Grb2-Sos, and protein tyrosine phosphatase type 11 (PTPN11 or SHP2). In humans, the pathological role of the protein has been detected in non-insulin-dependent diabetes mellitus. The gene encoding for rat IRS-1 maps to chromosome 9q34. | | | Catalog # | I8700-06A | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:100-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Rat | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.025% sodium azide, 50% glycerol. | | Purity | Serum. | | Immunogen | Synthetic peptide corresponding to aa1222-1235 (YASINFQKQPEDRQ) of rat IRS-1. | | Specificity | Recognizes rat IRS-1. Species sequence homology: chicken, human, mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | HIRS-1 |
External Links
|
