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You are here:Home » Antibodies » Abs to Transcription Factors, Homeobox (HOX) » Anti -ISL1 (IISL LIM Homeobox 1, Insulin Gene Enhancer Protein ISL-1, Isl-1, ISLET1, Islet-1)

Anti -ISL1 (IISL LIM Homeobox 1, Insulin Gene Enhancer Protein ISL-1, Isl-1, ISLET1,
Islet-1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Islet-1 (ISL-1) is a transcription factor that plays an important role in the embryogenesis of pancreatic islets of Langerhans. It is expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. In mouse embryos, a deficiency of this gene fail to undergo neural tube motor neuron differentiation. More recently it has been identified as a marker for a cardiac progenitor cell lineage that is capable of differentiating into all 3 major heart cell types: cardiomyocytes, smooth muscle and endothelial cell lineages.
Catalog #I8782-60A
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
ApplicationsSuitable for use in Western Blot, Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5 ug/mL detected ISL-1 on 10ug cell lysate.
Immunohistochemistry: 1:300 dilution from a previous lot detected ISL-1 in mouse pancreas tissue.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide
PurityPurified.
ImmunogenLinear peptide corresponding to Human ISL-1(KLH).
SpecificityRecognizes human ISL-1. Species Crossreactivity: mouse, hequine, bovine, sheep, rat, canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesISL1 Transcription Factor, LIM/homeodomain, (Islet-1)


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