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You are here:Home » Antibodies » Abs to Notch Proteins » Anti -JAG1 (Jagged1 AGS, AHD, AWS, HJ1, JAGL1, Alagille syndrome protein, hJ1, CD339 antigen, JAGL1)

Anti -JAG1 (Jagged1 AGS, AHD, AWS, HJ1, JAGL1, Alagille syndrome protein, hJ1, CD339
antigen, JAGL1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for multiple Notch receptors involved in the mediation of Notch signalling. It may be involved in cell-fate decision during hematopoiesis and seems to be involved in early and late stages of mammalian cardiovascular development. JAG1 is a trans membrane protein that is widely expressed in adult and fetal tissues. Mutations that alter the jagged 1 protein cause Alagille syndrome which is an autosomal dominant multisysstem disorder. Defects in JAG1 are also the cause of tetralogy of Fallot (TOF) which is a congenital heart anomaly.
Catalog #J0400-01G
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No9G373
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O.
PurityAscites
ImmunogenPartial recombinant corresponding to aa531-621 of human JAG1 with a GST tag.
SpecificityRecognizes human JAG1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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