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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -JAK1 (Tyrosine-protein Kinase JAK1, Janus Kinase 1, JAK-1, JAK1A, JAK1B)

Anti -JAK1 (Tyrosine-protein Kinase JAK1, Janus Kinase 1, JAK-1, JAK1A, JAK1B)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
JAK1 is a member of the JAK (Janus kinase) family of protein tyrosine kinases including 4 family members JAK1, JAK2, JAK3, and TYK2 and which gets activated in response to a wide variety of polypeptide ligands. The protein has a C-terminal protein tyrosine kinase domain, an adjacent kinase-related domain and five further domains with aa similarity between members of the family extending towards the Nterminus. JAK1 plays important role in mediating signal transduction by the type I interferon receptor. JAK1 mutation functions as disease-modifying mutations in acute myeloid leukemia (AML) pathogenesis. Human JAK1 gene is mapped to chromosomal region 1p32.3-p31.3.
Catalog #J0900-05H
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlMCF7 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human JAK1 around the phosphorylation site of tyrosine 1022 (K-E-YP-Y-T).
SpecificityRecognizes human JAK1. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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