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Abs to Tyrosine Kinases
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Anti -JAK1 (Tyrosine-protein Kinase JAK1, Janus Kinase 1, JAK-1, JAK1A, JAK1B)
Anti -JAK1 (Tyrosine-protein Kinase JAK1, Janus Kinase 1, JAK-1, JAK1A, JAK1B)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| JAK1 is a member of the JAK (Janus kinase) family of protein tyrosine kinases including 4 family members JAK1, JAK2, JAK3, and TYK2 and which gets activated in response to a wide variety of polypeptide ligands. The protein has a C-terminal protein tyrosine kinase domain, an adjacent kinase-related domain and five further domains with aa similarity between members of the family extending towards the Nterminus. JAK1 plays important role in mediating signal transduction by the type I interferon receptor. JAK1 mutation functions as disease-modifying mutations in acute myeloid leukemia (AML) pathogenesis. Human JAK1 gene is mapped to chromosomal region 1p32.3-p31.3. | | | Catalog # | J0900-05H | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Immunohistochemistry (paraffin): 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Positive Control | MCF7 cells | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic non-phosphopeptide corresponding to human JAK1 around the phosphorylation site of tyrosine 1022 (K-E-YP-Y-T). | | Specificity | Recognizes human JAK1. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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