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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -JAK2 (Tyrosine-protein Kinase JAK2, Janus Kinase 2, JAK-2)

Anti -JAK2 (Tyrosine-protein Kinase JAK2, Janus Kinase 2, JAK-2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
JAK 2 (Janus Activating Kinase 2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a variety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues as well as perhaps one or more serine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activators of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including ISGs (interferon-stimulated genes). JAK 2 plays an essential role in Interferon-gamma signaling.
Catalog #J0900-28E
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human Jak2 around the phosphorylation site of tyrosine 570 (G-D-YP-G-Q).
SpecificityRecognizes human JAK2. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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