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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -JAK2, phosphorylated (Tyr1007) (Tyrosine-protein Kinase JAK2, Janus Kinase 2, JAK-2)

Anti -JAK2, phosphorylated (Tyr1007) (Tyrosine-protein Kinase JAK2, Janus Kinase 2, JAK-2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
JAK2 is a member of the Jak kinase family which is ubiquitously expressed. It associates with cytokine receptors and is essential for signal transduction by mediating tyrosine phosphorylation. The protein is composed of four conserved domains, the NH2-terminal FERM domain which is required for interaction with cytokine receptors, the adjacent SH2-like fold with no known function, a kinase-like COOH-terminal JH2 domain that is devoid of enzymatic activity but that inhibits the activity of the COOH-terminal JH1 tyrosine kinase domain. Human JAK2 gene is localized in the chromosomal region 9p24. The protein is highly expressed in spleen, peripheral blood leukocytes, testis, heart and skeletal muscle. Recent studies have implicated de-regulation of JAK2 kinase activity by chromosomal translocations in hematopoietic tumors.
Catalog #J0901-05B
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human JAK2 around the phosphorylation site of tyrosine 1007 (K-E-YP-Y-K).
SpecificityRecognizes human JAK2, phosphorylated at Tyr1007. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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