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You are here:Home » Antibodies » Abs to Enzymes, Demethylase » Anti -JMJD1B, NT (JmjC Domain-containing Histone Demethylation Protein 2B, Jumonji Domain-containing Protein 1B, Nuclear Protein 5qNCA, JMJD1B, C5orf7, JHDM2B, KIAA1082, Lysine-specific Demethylase 3B) (AP)

Anti -JMJD1B, NT (JmjC Domain-containing Histone Demethylation Protein 2B, Jumonji
Domain-containing Protein 1B, Nuclear Protein 5qNCA, JMJD1B, C5orf7, JHDM2B, KIAA1082,
Lysine-specific Demethylase 3B) (AP)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Catalog #J7876-42C-AP
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:250-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Alkaline Phosphatase.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide selected from the N-terminal region of human JMJD1B (KLH).
SpecificityRecognizes human JMJD1B.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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