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You are here:Home » Antibodies » Abs to Enzymes, Demethylase » Anti -JMJD1B (JmjC Domain-containing Histone Demethylation Protein 2B, Jumonji Domain-containing Protein 1B, Nuclear Protein 5qNCA, JMJD1B, C5orf7, JHDM2B, KIAA1082, Lysine-specific Demethylase 3B)

Anti -JMJD1B (JmjC Domain-containing Histone Demethylation Protein 2B, Jumonji
Domain-containing Protein 1B, Nuclear Protein 5qNCA, JMJD1B, C5orf7, JHDM2B, KIAA1082,
Lysine-specific Demethylase 3B)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
JMJD1b, also known as Jumonji domain-containing protein 1b, is a 1761aa containing histone demethylase that specifically demethylates 'Lys-9' of histone H3, that generates formaldehyde and succinate, thereby playing a central role in histone code. A frequent deletion of this gene is found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del(5q) tumor suppressor gene and may have tumor suppressor activity. Reports suggest that it may also play a role in meiotic and postmeiotic germ cell development. JMJD1b, a member of the JHDM2 histone demethylase family, contains a JmjC domain and is ubiquitously expressed in most of the tissues with high expression in placenta, skeletal muscle, kidney, heart and liver.
Catalog #J7876-42D
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa858-875 of human JMJD1b GKSKGKQAPKGRPRTAPL.
SpecificityRecognizes human JMJD1b/jumonji domain containing 1b. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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