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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -JMJD3 (Lysine-specific Demethylase 6B, JmjC Domain-containing Protein 3, Jumonji Domain-containing Protein 3, Lysine Demethylase 6B, KDM6B, KIAA0346)

Anti -JMJD3 (Lysine-specific Demethylase 6B, JmjC Domain-containing Protein 3, Jumonji
Domain-containing Protein 3, Lysine Demethylase 6B, KDM6B, KIAA0346)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
JMJD3 is a 1641aa containing intracellular protein belonging to the UTX family with a JmjC domain. It has potent histone demethylase activity but is expressed mainly in an inducible and cell-type restricted fashion (histone H3K27-specific demethylase) and specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. JMJD3 is known to play a central role in regulation of posterior development, by regulating HOX gene expression. It is induced by inflammatory stimuli which is mediated by NF-kappa-B and is involved in inflammatory response by participating in macrophage differentiation.
Catalog #J7876-49B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa297-314 of mouse JMJD3 KGSAPPERQEQRHSMPHS.
SpecificityRecognizes mouse JMJD3. Species sequence homology: canine, equine, human, monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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