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You are here:Home » Antibodies » Abs to Retinoblastoma Proteins » Anti -Jumonji/ARID Domain Containing Protein 1A (JARID1A, KDM5A, Retinoblastoma Binding Protein 2, RBBP2, RBP2, Retinoblastoma Binding Protein 2 Homolog, RBP2-H1)

Anti -Jumonji/ARID Domain Containing Protein 1A (JARID1A, KDM5A, Retinoblastoma Binding
Protein 2, RBBP2, RBP2, Retinoblastoma Binding Protein 2 Homolog, RBP2-H1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
JMJD1a is a 1722aa containing histone demethylase that specifically demethylates 'Lys-4' of histone H3, and demethylates trimethylated and dimethylated, but not monomethylated, H3 'Lys-4' thus having a major role in histone code. Regulatory protein JMJD1a belongs to the JARID1 histone demethylase family with an ARID domain, a JMJC domain, a JMJN domain and three PHD-type zinc fingers. It is thought to stimulate transcription mediated by nuclear receptors. JMJD1a, involved in transcriptional regulation of Hox proteins during cell differentiation, may also participate in transcriptional repression of cytokines such as CXCL12. It interacts with the viral protein-binding domain of RB1 which regulates cell proliferation and with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. JMJD1a is a nuclear protein ubiquitously expressed in most of the tissues.
Catalog #J7876-49D
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa1690-1703 of human JMJD1a CAKKQGPVSPGPAP.
SpecificityRecognizes human JMJD1a. Species sequence homology: bovine, canine, equine, mouse, opossum, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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