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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -Junctional Adhesion Molecule 1 (Junctional Adhesion Molecule A, JAM-A, JAM-1, Platelet Adhesion Molecule 1, PAM-1, CD321, Platelet F11 Receptor, F11R, JAM1, JCAM, F11R, UNQ264/PRO301) (APC)

Anti -Junctional Adhesion Molecule 1 (Junctional Adhesion Molecule A, JAM-A, JAM-1,
Platelet Adhesion Molecule 1, PAM-1, CD321, Platelet F11 Receptor, F11R, JAM1, JCAM, F11R,
UNQ264/PRO301) (APC)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
The members of junctional adhesion molecules family are type I transmembrane receptors belonging to the immunoglobulin (Ig) superfamily. Human JAM-A, also known as platelet adhesion molecule 1 (PAM-1) and platelet F11 receptor, is predominantly expressed at intercellular junctions of both epithelial cells and endothelial cells. It is also expressed on circulating blood cells including neutrophils, monocytes, platelets, erythrocytes, and lymphocytes. JAM-A exhibits homophilic interactions to regulate tight junction assembly and modulate paracellular permeability. This homophilic interaction also mediates platelet aggregation and adhesion to endothelial cells and may play a role in thrombosis. The human and mouse proteins share ~67% aa sequence homology. Human JAM-A also shares ~35% and 32% aa sequence homology with human JAM-B and JAM-C.
Catalog #J8009-02A
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Excitation 620-650nm
Emission 660-670nm
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.
Clone TypeMonoclonal
IsotypeIgG1
Clone No12K120
HostMouse
SourceHuman
ConcentrationNot determined
Form.Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to human JAM-A expressed in NSO cell line.
SpecificityRecognizes human JAM-A.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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