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Anti -Junctional Adhesion Molecule C (JAM-C)
Anti -Junctional Adhesion Molecule C (JAM-C)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Affinity Purified |
E IP IH FC |
|
| Junctional adhesion molecule-C (JAM-C) also known as JAM-2 is a 45kD cell adhesion molecule (CAM). JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. In humans, JAM-C expression is not restricted to endothelial cells, but is also expressed on human lymphocytes. | | | Catalog # | J8025-01 | | Applications | Can be used for Immunoprecipiation, immunoassays as detector antibody, Immunohistology on frozen sections, Flow Cytometry and ELISA. Also useful for inhibition of biological activity. | | Recommended Dilution | Immunohistology: 1:10 | | Flow Cytometry: 1:10 | | ELISA: 1:10 | | For inhibition of biological activity dilutions have to be made according to the amounts of JAM-C to be inhibited. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 6A591 | | Host | Rat | | Source | Mouse | | Concentration | ~0.1mg/ml | | Immunogen | Recombinant, soluble JAM-2 | | Form | Supplied as a liquid in PBS, containing 0.1% BSA. | | Purity | Purified IgG | | Specificity | Recognizes mouse JAM-C. Also reacts with human JAM-C. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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