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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -Junctional Adhesion Molecule C (JAM-C)

Anti -Junctional Adhesion Molecule C (JAM-C)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified E IP IH FC
Junctional adhesion molecule-C (JAM-C) also known as JAM-2 is a 45kD cell adhesion molecule (CAM). JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. In humans, JAM-C expression is not restricted to endothelial cells, but is also expressed on human lymphocytes.
Catalog #J8025-01
ApplicationsCan be used for Immunoprecipiation, immunoassays as detector antibody, Immunohistology on frozen sections, Flow Cytometry and ELISA. Also useful for inhibition of biological activity.
Recommended DilutionImmunohistology: 1:10
Flow Cytometry: 1:10
ELISA: 1:10
For inhibition of biological activity dilutions have to be made according to the amounts of JAM-C to be inhibited.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No6A591
HostRat
SourceMouse
Concentration~0.1mg/ml
ImmunogenRecombinant, soluble JAM-2
FormSupplied as a liquid in PBS, containing 0.1% BSA.
PurityPurified IgG
SpecificityRecognizes mouse JAM-C. Also reacts with human JAM-C.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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