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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -Junctional Adhesion Molecule C (JAMC, JAM-C, FLJ14529, Junctional Adhesion Molecule 3, JAM3, JAM-3, UNQ859/PRO1868)

Anti -Junctional Adhesion Molecule C (JAMC, JAM-C, FLJ14529, Junctional Adhesion Molecule
3, JAM3, JAM-3, UNQ859/PRO1868)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rat Purified IP IH FC
JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. Monoclonal antibody CRAM-18 F26 also reacts with human JAM-C. In humans, JAM-C expression is not restricted to endothelial cells, but is also expressed on human lymphocytes.
Catalog #J8025-02
ApplicationsSuitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (frozen): 1:10
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No18F26
HostRat
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA.
PurityPurified
ImmunogenHuman JAM-C.
SpecificityRecognizes Junctional adhesion molecule-C (JAM-C) also known as JAM-2 is a 45kD cell adhesion molecule (CAM).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesJAM-2


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