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You are here:Home » Biochemicals » Biochem-Antibiotics » Antibiotic K252A (Antibiotic SF 2370)

Antibiotic K252A (Antibiotic SF 2370)


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Antibiotic K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. Antibiotic K252A exhibits potent antitumor activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. More extensive investigation has demonstrated that while antibiotic K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).
Catalog #K0000-50C
Source Nocardiopsis sp.
Apperance White solid
Solubility Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Sensitive to light.
CAS Number99570-78-2
Molecular FormulaC26H19N3O5
Molecular Weight453.5
SourceNocardiopsis sp.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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