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You are here:Home » Antibodies » Abs to Kallikrein » Anti -KLK2 (KLK2A2, MGC12201, hK2, Kallikrein-2, Tissue kallikrein-2)

Anti -KLK2 (KLK2A2, MGC12201, hK2, Kallikrein-2, Tissue kallikrein-2)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IC
KLK2 is a serine protease produced by secretory epithelial cells in the prostate (1). It is a glandular kallikrein that cleaves Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin (2). KLK2 can activate the proforms of PSA (prostate-specific antigen) and urokinase type plasminogen activator and inactivate plasminogen activator inhibitor-1, suggesting a possible role in a proteolytic cascade associated with prostate cancer. Thus, it may promote tumor growth, and metastasis and inhibition of KLK2 activity may, therefore, slow down tumor spread (1).
Catalog #K0005-05N
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000-1:10,000
Immunocytochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone NoEPR6676
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in human KLK2.
SpecificityRecognizes human KLK2. Species crossreactivity: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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