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You are here:Home » Antibodies » Abs to Kallikrein » Anti -Kallikrein 6 (KLK6) (Neurosin)

Anti -Kallikrein 6 (KLK6) (Neurosin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Neurosin (KLK6), one of these, is atrypsin-like protease dominantly expressed in the human brain but also in a variety of other tissues. The human tissue kallikrein gene family contains 15 members that play important roles in cancer. Notably, KLK1, also known as tissue kallikrein, cleaves kininogen to release the vasoactive kinin peptide, bradykinin or lysyl-bradykinin. KLK3, called prostate specific antigen (PSA), is an established tumor marker that aids in the diagnosis, staging, and follow up of prostate cancer. KLK4 is specifically expressed in the prostate and overexpressed in prostate cancer. KLK5 is widely expressed but found at high levels in skin, breast, brain and testis; overexpression is an indicator of poor prognosis in ovarian cancer. KLK8 is expressed in the brain and is a novel marker of ovarian and cervical cancer.
Catalog #K0005-09B
ApplicationsSuitable for use in ELISA and Western Blot
Recommended DilutionsELISA: 1:1000
HybridomaHybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Neurosin protein.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8G2
HostMouse
SourceHuman
Concentration1mg/ml
FormSupplied as a liquid In PBS, pH 7.4, with 0.1% Sodium Azide.
PurityPurified by protein-G affinity chromatography.
ImmunogenRecombinant human Neurosin (23-240aa) purified from E. coli
SpecificityRecognizes human Kallikrein 6 (KLK6) (Neurosin)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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