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You are here:Home » Antibodies » Abs to Kallikrein » Anti -Kallikrein 8 (hK8, Neuropsin, NP, Ovasin, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, Serine protease 19, KLK8, NRPN, PRSS19, TADG14)

Anti -Kallikrein 8 (hK8, Neuropsin, NP, Ovasin, Serine protease TADG-14, Tumor-associated
differentially expressed gene 14 protein, Serine protease 19, KLK8, NRPN, PRSS19, TADG14)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IF
Kalllikrein-8 is a serine protease capable of degrading several proteins such as casein, fibrinogen, kininogen, fibronectin and callagen type IV. It also cleaves L1CAM in response to increased neural activity. It induces neurite outgrowth and fasciculation of cultured hippocampal neurons. It plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. It is involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. It is Inhibited by a range of serine protease inhibitors including antipain, aprotinin, leupeptin, benzamidine and soybean trypsin inhibitor. It is a secreted protein that has 4 named isoforms produced by alternative splicing. Isoform 1 is predominantly expressed in the pancreas while isoform 2 is expressed in adult brain and hippocampus. Both forms are also found in fetal brain and placenta. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples.
Catalog #K0005-11A
ApplicationsSuitable for use in ELISA, Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20°C. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No9G374
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder in PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.
PurityPurified by affinity chromatography.
ImmunogenPartial recombinant human Kallikrein-8 (97-2040) with a GST tag.
SpecificityRecognizes human Kallikrein 8.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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