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Anti -Kallikrein B1 (KLKB1, Plasma Kallikrein)
Anti -Kallikrein B1 (KLKB1, Plasma Kallikrein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Affinity Purified |
E B |
|
| Kallikrein B1 (KLKB1) is a serine protease synthesized in the liver and circulated in the plasma by binding to high molecular weight (HMW) kininogen or as a free zymogen. It plays an important role in blood pressure regulation, fibrinolysis, and neutrophil activation. Mouse KLKB1 precursor contains a signal peptide (residues 1 to 19) and a pro form sequence (residues 20 to 638). Upon activation, the pro form is converted to a heavy chain and a light chain, which is linked by disulfide bonds and the latter contains the catalytic domain. The amino acid sequence of mouse KLKB1 is 90%, 77% and 76% identical to that of rat, canine and human. | | | Catalog # | K0005-28B | | Applications | Suitable for use in Western Blot and ELISA. Other applications not tested. | | Recommended Dilution | Western Blot: 1-2ug/ml | | ELISA: 0.5-1ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 7H97 | | Host | Rat | | Source | Mouse | | Concentration | As reported | | Form | Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | NS0-derived recombinant mouse KLKB1 (aa20-638) Accession # NP_032481 | | Specificity | Recognizes mouse Kallikrein B1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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