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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -Kappa B Ras 1 (kB-Ras1, 2400004O09Rik, IkB-interacting Ras-like Protein 1, NFkB Inhibitor-interacting Ras-like Protein 1, NKIRAS 1)

Anti -Kappa B Ras 1 (kB-Ras1, 2400004O09Rik, IkB-interacting Ras-like Protein 1, NFkB
Inhibitor-interacting Ras-like Protein 1, NKIRAS 1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB (1). Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-6). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified (1). One of the first genes induced following NF-kB activation is IkBa. Recently, two proteins, kB-Ras1 and kB-Ras2 have been identified (7). These two proteins interact with PEST domains of IkBa and IkBb and decrease their rate of degradation.
Catalog #K0079-50
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No8L509
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenThis monoclonal antibody was raised against a synthetic peptide containing amino acid residues 96-113 of human kB-Ras1.
SpecificitySpecies Crossreactivity: Human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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