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You are here:Home » Antibodies » Abs to Transport Proteins » Anti -Karyopherin beta 1 (KPNB1, Importin beta 1, IMB1, IPOB, Impnb, Importin 90, MGC2155, MGC2156, MGC2157, Nuclear Factor p97, NTF97)

Anti -Karyopherin beta 1 (KPNB1, Importin beta 1, IMB1, IPOB, Impnb, Importin 90, MGC2155,
MGC2156, MGC2157, Nuclear Factor p97, NTF97)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
Catalog #K0102-30B
Positive Control Daudi cell lysate
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH7.2, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide, C-RRSKTNKAKTLAT, representing the C Terminus of the human protein according to NP_002256.2. Homology: Mouse, Rat, Dog
SpecificitySpecies Crossreactivity: Human. Other species not tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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